The Murray Laboratory has been investigating newborn-related conditions since 1999. In 2005, we began studies focused on preterm birth.  Prematurity is defined as a birth occurring before 37 weeks gestation. One in eight pregnancies ends in preterm birth. Most of these deliveries are the result of preterm labor, but sometimes the cause is other medical factors that make it necessary to deliver the baby, such as preeclampsia. Our group has investigated the genetic and environmental factors leading to spontaneous preterm delivery, and how gene-environment interactions may make a difference. We have also studied the genetic influences in neonatal complications arising from preterm birth, such as intraventricular hemorrhage (IVH), patent ductus arteriosus (PDA) and retinopathy of prematurity (ROP).

Prematurity Publications

Boghossian NS, Hansen NI, Bell EF, Stoll BJ, Murray JC, Carey JC, Adams-Chapman I, Shankaran S, Walsh MC, Laptook AR, Faix RG, Newman NS, Hale EC, Das A, Wilson LD, Hensman AM, Grisby C, Collins MV, Vasil DM, Finkle J, Maffett D, Ball B, Lacy CB, Bara R, Higgins RD, for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network - Mortality and morbidity of VLBW infants with trisomy 13 or trisomy 18 - Pediatrics 2014 , Jan 20, 133(2) - PMID/PMC: 24446439

Lewińska M, Zelenko U, Merzel F, Golic Grdadolnik S, Murray JC, Rozman D - Polymorphisms of CYP51A1 from Cholesterol Synthesis: Associations with Birth Weight and Maternal Lipid Levels and Impact on CYP51 Protein Structure - PLoS One 2013 , Dec 17; 8(12):e82554 - PMID/PMC: 24358204

Lackritz EM, Wilson CB, Guttmacher AE, Howse JL, Engmann CM, Rubens CE, Mason EM, Muglia LJ, Gravett MG, Goldenberg RL, Murray JC, Spong CY, Simpson JL, the Preterm Birth Research Priority Setting Group - A solution pathway for preterm birth: Accelerating a priority research agenda - The Lancet Global Health 2013 , 15 Nov 2013 - PMID/PMC:

Zheng X, Feingold E, Ryckman KK, Shaffer JR, Boyd HA, Feenstra B, Melbye M, Marazita ML, Murray JC, Cuenco KT - Association of maternal CNVs in GSTTGSTT2 with smoking, preterm delivery, and low birth weight - Front. Genet. 2013 , Oct 28; 4:196. - PMID/PMC: PMC3809558

Feenstra B, Geller F, Carstensen L, Romitti PA, Korberg, IB, Bedell B, Krogh C, Fan R, Svenningsson A, Caggana M, Nordenskjold A, Mills JL, Murray JC, Melbye M. - Plasma lipids, genetic variants near APOA1, and the risk of infantile hypertrophic pyloric stenosis. - JAMA 2013 , ug 21;310(7):714-721 - PMID/PMC: 23989729

Kim J, Stirling KJ, Cooper ME, Ascoli M, Momany AM, McDonald EL, Ryckman KK, Rhea L, Schaa KL, Cosentino V, Gadow E, Saleme C, Shi M, Hallman M, Plunkett J, Teramo KA, Muglia LJ, Feenstra B, Geller F, Boyd HA, Melbye M, Marazita ML, Dagle JM, Murray JC - Sequence variants in oxytocin pathway genes and preterm birth: a candidate gene association study - BMC Med Genet 2013 , Jul 26; 14(1):77 - PMID/PMC: 23889750

Adén U, Lin A, Carlo W, Leviton A, Murray JC, Hallman M, Lifton RP, Zhang H, Ment LR - Gene Targets for Intraventricular Hemorrhage Study Group. Candidate Gene Analysis: Severe Intraventricular Hemorrhage in Inborn Preterm Neonates - J Pediatr 2013 , Jul 26, 163(5):1503-1506 - PMID/PMC: 23896193

Alleman BW, Bell EF, Li L, Dagle JM, Smith PB, Ambalavanan N, Laughon MM, Stoll BJ, Goldberg RN, Carlo WA, Murray JC, Cotten CM, Shankaran S, Walsh MC, Laptook AR, Ellsbury DL, Hale EC, Newman NS, Wallace DD, Das A, Higgins RD; for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network - Individual and Center-Level Factors Affecting Mortality Among Extremely Low Birth Weight Infants - Pediatrics 2013 , July; 132(1):e175-e184 - PMID/PMC: 23753096

Adams-Chapman I, Hansen NI, Shankaran S, Bell EF, Boghossian NS, Murray JC, Laptook AR, Walsh MC, Carlo WA, Sánchez PJ, Van Meurs KP, Das A, Hale EC, Newman NS, Ball MB, Higgins RD, Stoll BJ; for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network - Ten-Year Review of Major Birth Defects in VLBW Infants - Pediatrics 2013 , Jul;132(1):49-61 - PMID/PMC: 23733791

Mohamed S, Murray JC, Dagle JM, Colaizy T - Hyperglycemia as a risk factor for the development of retinopathy of prematurity - BMC Pediatr 2013 , May 16; 13(1):78 - PMID/PMC: 23679669

McElroy JJ, Gutman CE, Shaffer CM, Busch TD, Puttonen H, Teramo K, Murray JC, Hallman M, Muglia LJ - Maternal coding variants in complement receptor 1 and spontaneous idiopathic preterm birth - Hum Genet 2013 , Apr 17, in press - PMID/PMC: 23591632

Ryckman KK, Shchelochkov OA, Cook DE, Berberich SL, Copeland S, Dagle JM, Murray JC - The influence of maternal disease on the metabolites measured as part of newborn screening - J Matern Fetal Neonatal Med 2013 , Aug;132(8):935-42 - PMID/PMC: 23591632

Alleman BW, Smith AR, Byers HM, Bedell B, Ryckman KK, Murray JC, Borowski KS - A proposed method to predict preterm birth using clinical data, standard maternal serum screening, and cholesterol - Am J Obstet Gynecol 2013 , Mar 15 - PMID/PMC: 23500456

Myking S, Boyd HA, Myhre R, Feenstra B, Jugessur A, Devold Pay AS, Ostensen IH, Morken NH, Busch T, Ryckman KK, Geller F, Magnus P, Gjessing HK, Melbye M, Jacobsson B, Murray JC - X-chromosomal maternal and fetal SNPs and the risk of spontaneous preterm delivery in a DanisNorwegian genome-wide association study - PLoS ONE 2013 , 8(4):e61781 - PMID/PMC: 23613933

Ryckman KK, Dagle JM, Shchelochkov OA, Ehinger N, Poole SD, Berberich SL, Reese J, Murray JC - Association of amino acids with common complications of prematurity - Pediatr Res 2013 , Jun; 73(6):700-705 - PMID/PMC: 23481552

Boghossian NS, Page GP, Bell EF, Stoll BJ, Murray JC, Cotten CM, Shankaran S, Walsh MC, Laptook AR, Newman NS, Hale EC, McDonald SA, Das A, Higgins RD; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network - Late-onset sepsis in very low birth weight infants from singleton and multiple gestation births - J Pediatr 2013 , Pii: S0022-3476(12)01423-0 - PMID/PMC: 23324523

Kim J, Pitlick MM, Christine PJ, Schaefer AR, Saleme C, Comas B, Costentino V, Gadow E, Murray JC - Genome-wide analysis of DNA methylation in human amnion - Scientific World Journal 2013 , 678156 - PMID/PMC: 23533356

Alul F, Shchelochkov OA, Berberich SL, Murray JC, Ryckman KK - Genetic associations with neonatal thyroid stimulating hormone levels - Pediatr Res 2013 , 73(4 Pt 1):484-491 - PMID/PMC: 23344678

Dagle JM, Murray JC - Applying deep DNA sequencing to common, complex pediatric traits - Pediatrics 2012 , Dec; 130(6):e1677-1678 - PMID/PMC: 23166345

Krupitzki HB, Gadow EC, Gili JA, Comas B, Cosentino VR, Saleme C, Murray JC, Camelo JS - Environmental risk factors and perinatal outcomes in preterm newborns, according to family recurrence of prematurity - Am J Perinatol 2013 , Jun; 30(6):451-462. - PMID/PMC: 23132119

Bream ENA, Zimmerman CR, Cooper ME, Dagle JM, Merrill DC, Christensen K, Simhan HN, Fong CT, Hallmann M, Muglia LJ, Marazita ML, and Murray JC - Candidate gene linkage approach to preterm delivery - Pediatr Res 2013 , Feb; 73(2):135-141 - PMID/PMC: 23168575

Mann PC, Cooper ME, Ryckman KK, Comas B, Gili J, Crumley S, Bream EN, Byers HM, Piester T, Schaefer A, Christine PJ, Lawrence A, Schaa KL, Kelsey KJ, Berends SK, Momany AM, Gadow E, Cosentino V, Castilla EE, López Camelo J, Saleme C, Day LJ, England SK, Marazita ML, Dagle JM, Murray JC - Polymorphisms in the fetal progesterone receptor and a calcium-activated potassium channel isoform are associated with preterm birth in an Argentinian population - J Perinatol 2013 , May; 33(5):336-340 - PMID/PMC: 23018797

Ryckman KK, Berberich SL, Shchelochkov OA, Cook DE, Murray JC - Clinical and environmental influences on metabolic biomarkers collected for newborn screening. - Clin Biochem 2012 , Sep 23 [Epub ahead of print] - PMID/PMC: 23010448

Falah N, McElroy J, Snegovskikh V, Lockwood CJ, Norwitz E, Murray JC, Kuczynski E, Menon R, Teramo K, Muglia LJ, Morgan T - Investigation of genetic risk factors for chronic adult diseases for association with preterm birth. - Hum Genet 2012 , Sep 13 [Epub ah ead of print] - PMID/PMC: 22972380

Falah N, McElroy J, Snegovskikh V, Lockwood CJ, Norwitz E, Murray JC, Kuczynski E, Menon R, Teramo K, Muglia LJ, Morgan T - Investigation of genetic risk factors for chronic adult diseases for association with preterm birth. - Hum Genet 2012 , Sep 13 [Epub ahead of print] - PMID/PMC: 22972380

Tyrrell J, Huikari V, Christie JT, Cavadino A, Bakker R, Brion MJ, Geller F, Paternoster L, Myhre R, Potter C, Johnson PC, Ebrahim S, Feenstra B, Hartikainen AL, Hattersley AT, Hofman A, Kaakinen M, Lowe LP, Magnus P, McConnachie A, Melbye M, Ng JW, Nohr EA, Power C, Ring SM, Sebert SP, Sengpiel V, Taal HR, Watt GC, Sattar N, Relton CL, Jacobsson B, Frayling TM, Sørensen TI, Murray JC, Lawlor DA, Pennell CE, Jaddoe VW, Hypponen E, Lowe WL Jr, Jarvelin MR, Davey Smith G, Freathy RM; for the Early Growth Genetics (EGG) Consortium - Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) interacts with maternal self-reported smoking status during pregnancy to influence birth weight. - Hum Mol Genet 2012 , Sep 17 [Epub ahead of print] - PMID/PMC: 22956269

Alleman B, Myking S, Ryckman K, Myhre R, Feingold E, Feenstra B, Geller F, Boyd H, Shaffer J, Zhang Q, Begum F, Crosslin D, Doheny K, Pugh E, Pay A, Ostensen I, Morken N-H, Magnus P, Marazita M, Jacobsson B, Melbye M - No observed association for mitochondrial SNPs with preterm delivery and related outcomes. - Pediatr Res 2012 , Aug 17 [Epub ahead of print] - PMID/PMC: 22902432

Alul FY, Cook DE, Shchelochkov OA, Berberich SL, Murray JC, Ryckman KK - The heritability of metabolic profiles in newborn twins. - Heredity 2012 , - PMID/PMC:

Ryckman KK, Cook DE, Berberich SL, Shchelochkov )A, Berends S, Busch T, Dagle J, Murray JC - Replication of clinical associations with 17-hydroxyprogesterone in preterm newborns - J Pediatr Endocr Met 2012 , May 9 [Epub ahead of print] - PMID/PMC: 22768660

Kitzman JO, Snyder MW, Ventura M, Lewis AP, Qiu R, Simmons LE, Gammill HS, Rubens CE, Santillan DA, Murray JC, Tabor HK, Bamshad MJ, Eichler EE, Shendure J - Noninvasive whole genome sequencing of a human fetus. - Sci Transl Med 2012 , Jun 6; 4(137):137ra76 - PMID/PMC: 22674554

Pappas A, Shankaran S, Hansen NI, Bell EF, Stoll BJ, Laptook AR, Walsh MC, Das A, Bara R, Hale EC, Newman NS, Boghossian NS, Murray JC, Cotton CM, Adams-Chapman I, Hamrick S, Higgins - Outcome of extremely preterm infants (<1000 g) with congenital heart defects from the National Institute of Child Health and Human Development Neonatal Research Network. - Pediatr Cardiol 2012 , Epub 30 May - PMID/PMC: 22644414

Kim J, Zhao K, Jiang P, Lu ZX, Wang J, Murray JC, Xing K. - Transcriptome landscape of the human placenta. - BMC Genomics 2012 , Mar 27; 13(1):115 - PMID/PMC: 22448651

Taal HR, St Pourcain B, Thiering E, Das S, Mook-Kanamori DO, Warrington NM, Kaakinen M, Kreiner-Møller E et. al - Common variants at 12q15 and 12q24 are associated with infant head circumference - Nat Genet 2012 , Apr 15; 44(5):532-538 - PMID/PMC: 22504419

Feenstra B, Geller F, Krogh C, Hollegaard MV, Gortz S, Boyd HA, Murray JC, Hougaard DM, Melbye M - Common Variants near MBNL1 and NKX2-5 are Associated with Infantile Hypertrophic Pyloric Stenosis - Nat Genet 2012 , Feb 5; 44(3):334-347 - PMID/PMC: 22306654

Boghossian NS, Horbar JD, Murray JC, Carpenter JH for the Vermont Oxford Network - Anthropometric Charts for Infants with Trisomies 21, 18 or 13 Born Between 22 weeks Gestation and Term: The VON Charts - Am J Med Genet A 2012 , 158A(2):322-332 - PMID/PMC: 22246859

Boghossian NS, Horbar JD, Carpenter JH, Murray JC, Bell EF; Vermont Oxford Network. - Major Chromosomal Anomalies among Very Low Birth Weight Infants in the Vermont Oxford Network. - J Pediatr 2011 , May 160(5):774-780e11 - PMID/PMC: 22177989

Ryckman KK, Dagle JM, Kelsey K, Momany A, Murray JC. - Genetic associations of surfactant protein D and angiotensin-converting enzyme with lung disease in preterm neonates. - J Perinatol 2011 , May 32(5):349-355 - PMID/PMC: 21960125

Ryckman KK, Feenstra B, Shaffer JR, Bream EN, Geller F, Feingold E, Weeks DE, Gadow E, Cosentino V, Saleme C, Simhan HN, Merrill D, Fong CT, Busch T, Berends SK, Comas B, Camelo JL, Boyd H, Laurie CC, Crosslin D, Zhang Q, Doheny KF, Pugh E, Melbye M, Marazita ML, Dagle JM, Murray JC - Replication of a Genome-Wide Association Study of Birth Weight in Preterm Neonates - J Pediatr 2012 , 160(1):19-24.e4 - PMID/PMC: 21885063

Wehby GL, Fletcher JM, Lehrer SF, Moreno LM, Murray JC, Wilcox A, Lie RT - A genetic instrumental variables analysis of the effects of prenatal smoking on birth weight: evidence from two samples - Biodemography Soc Biol 2011 , 57(1):3-32 - PMID/PMC: 21845925

Wehby GL, Prater K, McCarthy AM, Castilla EE, Murray JC - The impact of maternal smoking during pregnancy on early child neurodevelopment - Journal of Human Capital 2011 , 5(2):207-254 - PMID/PMC: 22272363

Byers HM, Dagle JM, Klein JM, Ryckman KK, McDonald EL, Murray JC, Borowski KS - Variations in CRHR1 are associated with persistent pulmonary hypertension of the newborn - Pediatr Res 2012 , 71(2):162-167 - PMID/PMC: 22258127

Ryckman KK, Dagle JM, Kelsey K, Momany AM, Murray JC. - Replication of genetic associations in the inflammation, complement, and coagulatin pathways with intraventricular hemorrhage in LBW preterm neonates. - Pediatr Res 2011 , 70(1):90-95 - PMID/PMC: 21659962

Dagle JM, Fisher TJ, Haynes SE, Berends SK, Brophy PD, Morriss FH Jr, Murray JC. - Cytochrome P450 (CYP2D6) genotype is associated with elevated systolic blood pressure in preterm infants after discharge from the neonatal intensive care unit. - J Pediatr 2011 , 159(1):104-109 - PMID/PMC: 21353244

Haataja R, Karjalainen MK, Luukkonen A, Teramo K, Puttonen H, Ojaniemi M, Varilo T, Chaudhari BP, Plunkett J, Murray JC, McCarroll SA, Peltonen L, Muglia LJ, Palotie A, Hallman M - Mapping a new spontaneous preterm birth susceptibility gene, IGF1R, using linkage, haplotype sharing, and association analysis - PLoS Genet 2011 , 7(2):e1001293 - PMID/PMC: 21304894

Day LJ, Schaa JL, Ryckman KK, Dagle JM, Fong CT, Simhan HN, Merrill DC, Murray JC, England SK. - Single nucleotide polymorphisms in the KCNN3 gene associate with preterm birth. - Reproductive Sciences 2011 , Feb 1. [Epub ahead] - PMID/PMC: 21266667

Kao JS, Dawson JD, Murray JC, Dagle JM, Berends SK, Gillen SB, Bell EF. - Possible roles of bilirubin and breast milk in protection against retinopathy of prematurity. - Acta Paediatr. 2011 , Mar;100(3):347-51 - PMID/PMC: 20969622

Mumtaz G, Nassar AH, Mahfoud Z, El-Khamra A, Al-Choueiri N, Adra A, Murray JC, Zalloua P, Yunis KA. - Consanguinity: a risk factor for preterm birth at less than 33 weeks' gestation. - Am J Epidemiol. 2010 , Dec 15;172(12):1424- - PMID/PMC: 20978088

Boghossian NS, Hansen NI, Bell EF, Stoll BJ, Murray JC, Laptook AR, Shankaran S, Walsh MC, Das A, Higgins RD; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. - Survival and morbidity outcomes for very low birth weight infants with Down syndrome. - Pediatrics 2010 , Dec;126(6):1132-40 - PMID/PMC: 21098157

Waleh N, Hodnick R, Jhaveri N, McConaghy S, Dagle J, Seidner S, McCurnin D, Murray JC, Ohls R, Clyman RI. - Patterns of gene expression in the ductus arteriosus are related to environmental and genetic risk factors for persistent ductus patency. - Pediatr Res. 2010 , Oct;68(4):292-7. - PMID/PMC: 20581741

Abu-Maziad A, Schaa K, Bell EF, Dagle JM, Cooper M, Marazita ML, Murray JC. - Role of polymorphic variants as genetic modulators of infection in neonatal sepsis. - Pediatr Res. 2010 , Oct;68(4):323-9. - PMID/PMC: 20463618

Boyd HA, Poulsen G, Wohlfahrt J, Murray JC, Feenstra B, Melbye M. - Maternal contributions to preterm delivery. - Am J Epidemiol. 2009 , Dec 1;170(11):1358-6 - PMID/PMC: 19854807

Bille C, Pedersen DA, Andersen AM, Mansilla MA, Murray JC, Christensen K, Ballard JL, Gorman EB, Cabrera RM, Finnell RH. - Autoantibodies to folate receptor alpha during early pregnancy and risk of oral clefts in Denmark. - Pediatr Res. 2010 , Mar;67(3):274-9. - PMID/PMC: 19952865

Dagle JM, Lepp NT, Cooper ME, Schaa KL, Kelsey KJ, Orr KL, Caprau D, Zimmerman CR, Steffen KM, Johnson KJ, Marazita ML, Murray JC. - Determination of genetic predisposition to patent ductus arteriosus in preterm infants. - Pediatrics. 2009 , Apr;123(4):1116-23. - PMID/PMC: 19336370

Mohamed S, Schaa K, Cooper ME, Ahrens E, Alvarado A, Colaizy T, Marazita ML, Murray JC, Dagle JM. - Genetic contributions to the development of retinopathy of prematurity. - Pediatr Res. 2009 , Feb;65(2):193-7. - PMID/PMC: 18787502

Steffen KM, Cooper ME, Shi M, Caprau D, Simhan HN, Dagle JM, Marazita ML, Murray JC. - Maternal and fetal variation in genes of cholesterol metabolism is associated with preterm delivery. - J Perinatol. 2007 , Nov;27(11):672-80. E - PMID/PMC: 17855807

Ehn NL, Cooper ME, Orr K, Shi M, Johnson MK, Caprau D, Dagle J, Steffen K, Johnson K, Marazita ML, Merrill D, Murray JC. - Evaluation of fetal and maternal genetic variation in the progesterone receptor gene for contributions to preterm birth. - Pediatr Res. 2007 , Nov;62(5):630-5. - PMID/PMC: 17805208